Palabras clave
nutrition
treatments
lean mass
elderly ejercicio
nutrición
tratamientos
masa magra
adulto mayor exercício
nutrição
tratamentos
massa magra
idoso
Cómo citar
Resumen
La sarcopenia se caracteriza por la pérdida de la masa muscular y la fuerza. El objetivo fue determinar el tamaño del efecto global del tratamiento con ejercicio y/o suplementación sobre la masa muscular de personas adultas mayores diagnosticadas con sarcopenia, así como identificar las variables que moderan el efecto del tratamiento. Con respecto al método, se realizó una búsqueda de literatura en las bases de datos EBSCOhost, Ovid, ProQuest, PubMed, ScienceDirect, SpringerLink, Embase. De 4770 estudios recuperados, se incluyeron los 14 que cumplieron los criterios de inclusión: analizar la masa muscular, emplear diseños experimentales, aportar la estadística descriptiva, administrar un programa de ejercicio, suplementación o combinado de estas intervenciones e incluir personas mayores de 60 años diagnosticadas con sarcopenia. Los estudios debían estar publicados en texto completo en inglés o español. El cálculo del tamaño de efecto global se siguió utilizando el modelo de efectos aleatorios. En los resultados, fueron analizados 818 sujetos pertenecientes al grupo experimental y 284 al grupo control. Se obtuvo un tamaño de efecto global de 0.16 (p=0.005), procedente de 38 tamaños de efecto. El gráfico de funnel plot y la prueba de Egger no evidenciaron la presencia de sesgo general, ni publicación. Se necesitan 23 estudios para que el tamaño de efecto global sea no significativo. En la conclusión, se evidencia un cambio significativo en la masa muscular de personas adultas mayores diagnosticadas con sarcopenia, utilizando el tipo de intervención de ejercicio contra-resistencia con o sin suplementación; asimismo, se establece una guía de recomendaciones sobre prescripción de ejercicio y suplementación.
Citas
Alemán, H., Macías, L., Esparza, J., Astiazaran, H., & Blancas, A. L. (2012). Physiological effects beyond the significant gain in muscle mass in sarcopenic elderly men: evidence from a randomized clinical trial using a protein-rich food.Clinical interventions in aging,7, 225-234. doi: https://dx.doi.org/10.2147%2FCIA.S32356
Antoniak, A., & Greig, C. (2017). The effect of combined resistance exercise training and vitamin D3 supplementation on musculoskeletal health and function in older adults: a systematic review and meta-analysis.BMJ open,7(7), e014619. doi: http://dx.doi.org/10.1136/bmjopen-2016-014619
Balachandran, A., Krawczyk, S. N., Potiaumpai, M., & Signorile, J. F. (2014). High-speed circuit training vs hypertrophy training to improve physical function in sarcopenic obese adults: a randomized controlled trial.Experimental gerontology, 60, 64-71. doi: https://doi.org/10.1016/j.exger.2014.09.016
Beaudart, C., Dawson, A., Shaw, S., Harvey, N., Kanis, J., Binkley, N., Reginster, J., Chapurlat, R., Chan, D., Bruyére, O., Rizzoli, R., Cooper, C., & Dennison, E. (2017). Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review.Osteoporosis International, 28, 1817-1833. Recuperado de: https://link.springer.com/article/10.1007/s00198-017-3980-9
Beelen, M., Koopman, R., Gijsen, A., Vandereyt, H., Kies, A., Kuipers, H., ... & van Loon, L. J. (2008). Protein coingestion stimulates muscle protein synthesis during resistance-type exercise. American Journal of Physiology-Endocrinology and Metabolism, 295(1), E70-E77. doi: https://doi.org/10.1152/ajpendo.00774.2007
Burgos, R. (2006). Enfoque terapéutico global de la sarcopenia.Nutrición Hospitalaria, 21, 51-60. Recuperado de: http://scielo.isciii.es/scielo.php?pid=S0212-16112006 000600008&script=sci_arttext&tlng=pt
Candow, D., & Chilibeck, P. (2007). Timing of creatine or protein supplementation and resistance training in the elderly. Applied Physiology, Nutrition, and Metabolism, 33(1), 184-190. doi: https://doi.org/10.1139/H07-139
Carlsson, M., Littbrand, H., Gustafson, Y., Lundin, L., Lindelöf, N., Rosendahl, E., & Håglin, L. (2011). Effects of high-intensity exercise and protein supplement on muscle mass in ADL dependent older people with and without malnutrition—A randomized controlled trial. The journal of nutrition, health & aging, 15(7), 554-560. doi: https://doi.org/10.1007/s12603-012-0068-2
Cermak, N., de Groot, L., Saris, W., & van Loon, L. (2012). Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis.The American journal of clinical nutrition,96(6), 1454-1464. doi: https://doi.org/10.3945/ajcn.112.037556
Chen, H. T., Chung, Y. C., Chen, Y. J., Ho, S. Y., & Wu, H. J. (2017). Effects of Different Types of Exercise on Body Composition, Muscle Strength, and IGF‐1 in the Elderly with Sarcopenic Obesity.Journal of the American Geriatrics Society, 65(4), 827-832. doi: https://doi.org/10.1111/jgs.14722
Chun, D., Tsauo, J., Wu, Y., Cheng, C., Chen, H., Huang, Y., ... & Liou, T. (2017). Effects of protein supplementation combined with resistance exercise on body composition and physical function in older adults: a systematic review and meta-analysis.The American Journal of Clinical Nutrition, 106(4), 1078-1091. doi: https://doi.org/10.3945/ajcn.116.143594
Cribb, P., & Hayes, A. (2006). Effects of supplement-timing and resistance exercise on skeletal muscle hypertrophy. Medicine & Science in Sports & Exercise, 38(11), 1918-1925. Recuperado de: http://vuir.vu.edu.au/1436/
Cruz-Jentoft, A.J., Baeyens, J.P., Bauer, J.M., Boirie, Y., Cederholm, T., Landi, F., ... & Zamboni, M. (2010). Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People.Age & Ageing, 39(4),412-423. doi: https://doi.org/10.1093/ageing/afq034
Csapo, R., & Alegre, L. (2016). Effects of resistance training with moderate vs heavy loads on muscle mass and strength in the elderly: A meta‐analysis.Scandinavian journal of medicine & science in sports, 26(9), 995-1006. doi: https://doi.org/10.1111/sms.12536
Cohen, J. (1988). Statistical Power Analysis for the Behavioral sciences. Hillsdale: Lawrence Erlbaum Associates, Publicshers. Recuperado de: http://www.utstat.toronto.edu/~brunner/oldclass/378f16/readings/CohenPower.pdf
Drummond, M., Dreyer, H., Pennings, B., Fry, C., Dhanani, S., Dillon, E., Sheffield, M., Volpi, E., & Rasmussen, B. (2008). Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. Journal of applied physiology, 104(5), 1452-1461. doi: https://doi.org/10.1152/japplphysiol.00021.2008
Esmarck, B., Andersen, J., Olsen, S., Richter, E., Mizuno, M., & Kjær, M. (2001). Timing of postexercise protein intake is important for muscle hypertrophy with resistance training in elderly humans. The Journal of physiology, 535(1), 301-311. doi: https://doi.org/10.1111/j.1469-7793.2001.00301.x
Fiatarone, M., Marks, E., Ryan, N., Meredith, C., Lipsitz, L., & Evans, W. (1990). High-intensity strength training in nonagenarians: effects on skeletal muscle. Jama, 263(22), 3029-3034. Recuperado de: https://www.researchgate.net/publication/20814302_High-Intensity_Strength_Training_in_Nonagenarians_Effects_on_Skeletal_Muscle
Frontera, W., Meredith, C., O'Reilly, K., Knuttgen, H., & Evans, W. (1988). Strength conditioning in older men: skeletal muscle hypertrophy and improved function. Journal of applied physiology, 64(3), 1038-1044. doi: https://doi.org/10.1152/jappl.1988.64.3.1038
Goodman, C., Henry, G., Dawson, B., Gillam, I., Beilby, J., Ching, S., ... & Morling, P. (1997). Biochemical and ultrastructural indices of muscle damage after a twenty-one kilometer run. Australian journal of science and medicine in sport, 29(4), 95-98. doi: 10.1016/S1076-0512(97)80027-1
Kemmler, W., Teschler, M., Weissenfels, A., Bebenek, M., von Stengel, S., Kohl, M., ... & Engelke, K. (2016). Whole-body electromyostimulation to fight sarcopenic obesity in community-dwelling older women at risk. Results of the randomized controlled FORMOsA-sarcopenic obesity study. Osteoporosis International, 27(11), 3261-3270. doi: 10.1007/s00198-016-3662-z.
Kim, H., Kim, M., Kojima, N., Fujino, K., Hosoi, E., Kobayashi, H., ... & Yoshida, H. (2016). Exercise and nutritional supplementation on community-dwelling elderly Japanese women with sarcopenic obesity: a randomized controlled trial. Journal of the American Medical Directors Association, 17(11), 1011-1019. doi: https://doi.org/10.1016/j.jamda.2016.06.016
Kim, H., Suzuki, T., Saito, K., Yoshida, H., Kobayashi, H., Kato, H., & Katayama, M. (2012a). Effects of exercise and amino acid supplementation on body composition and physical function in community‐dwelling elderly Japanese sarcopenic women: a randomized controlled trial.Journal of the American Geriatrics Society, 60, 16-23. doi: https://doi.org/10.1111/j.1532-5415.2011.03776.x
Kim, H., Suzuki, T., Saito, K., Yoshida, H., Kojima, N., Kim, M., ... & Tokimitsu, I. (2012b). Effects of exercise and tea catechins on muscle mass, strength and walking ability in community‐dwelling elderly Japanese sarcopenic women: a randomized controlled trial.Geriatrics & gerontology international, 13(2), 458-465. doi: https://doi.org/10.1111/j.1447-0594.2012.00923.x
Koopman, R., Saris, W., Wagenmakers, A., & van Loon, L. (2007). Nutritional interventions to promote post-exercise muscle protein synthesis. Sports medicine, 37(10), 895-906. doi: 10.2165/00007256-200737100-00005
Latham, N., Bennett, D., Stretton, C., & Anderson, C. (2004). Systematic review of progressive resistance strength training in older adults. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 59(1), M48-M61. doi: https://doi.org/10.1093/gerona/59.1.M48
Lee, J., Kim, D., & Kim, C. (2017). Resistance Training for Glycemic Control, Muscular Strength, and Lean Body Mass in Old Type 2 Diabetic Patients: A Meta-Analysis.Diabetes Therapy, 8, 459-473. doi: https://dx.doi.org/10.1007%2Fs13300-017-0258-3
Leenders, M., & van Loon, L. (2011). Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes. Nutrition reviews, 69(11), 675-689. doi: https://doi.org/10.1111/j.1753-4887.2011.00443.x
Lera, L., Ángel, B., Sánchez, H., Picrin, Y., Hormazabal, M., Quiero, A., & Albala, C. (2015). Estimación y validación de puntos de corte de índice de masa muscular esquelética para la identificación de sarcopenia en adultos mayores chilenos. Nutrición Hospitalaria, 31(3), 1187-1197. Recuperado de: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112015000300027
Liberati, A., Altman, D., Tetzlaff, J., Mulrow, C., Gøtzsche, P., Ioannidis, J., ... & Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.PLoS medicine, 6(7), e1000100. doi: https://doi.org/10.1371/journal.pmed.1000100
Liu, C., & Latham, N. (2009). Progressive resistance strength training for improving physical function in older adults. The Cochrane Library. doi: https://dx.doi.org/ 10.1002%2F14651858.CD002759.pub2
Maltais, M., Ladouceur, J., & Dionne, I. (2016). The effect of resistance training and different sources of postexercise protein supplementation on muscle mass and physical capacity in sarcopenic elderly men. The Journal of Strength & Conditioning Research, 30(6), 1680-1687. doi: https://doi.org/10.1519/JSC.0000000000001255
Mascher, H., Andersson, H., Nilsson, P., Ekblom, B., & Blomstrand, E. (2007). Changes insignalling pathways regulating protein synthesis in human muscle in the recovery period after endurance exercise. Acta Physiologica, 191(1), 67-75. doi: https://doi.org/10.1111/j.1748-1716.2007.01712.x
McArdle, W., Katch, F., & Katch, V. (2015). Fisiología del ejercicio: nutrición rendimiento y salud. Wolters Kluver Health España, S.A. Recuperado de: https://www.casadellibro.com/libro-fisiologia-del-ejercicio-nutricion-rendimiento-y- salud/9788416004706/2516279
Meng, S., & Yu, L. (2010). Oxidative stress, molecular inflammation and Sarcopenia. International journal of molecular sciences, 11(4), 1509-1526. doi: http://dx.doi.org/10.3390/ijms11041509
Mitchell, C., Oikawa, S., Ogborn, D., Nates, N., MacNeil, L., Tarnopolsky, M., & Phillips, S. (2014). Daily chocolate milk consumption does not enhance the effect of resistance training in young and old men: a randomized controlled trial. Applied Physiology, Nutrition, and Metabolism, 40(2), 199-202. Recuperado de: http://www.nrcresearch press.com/doi/abs/10.1139/apnm-2014-0329#.W3epxehKjIU
Mitsiopoulos, N., Baumgartner, R., Heymsfield, S., Lyons, W., Gallagher, D., & Ross, R. (1998). Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography. Journal of applied physiology, 85(1), 115-122. doi: https://doi.org/10.1152/jappl.1998.85.1.115
Morley, J., Argiles, J., Evans, W., Bhasin, S., Cella, D., Deutz, N., ... & Kalantar, K. (2010). Nutritional recommendations for the management of sarcopenia. Journal of the American Medical Directors Association, 11(6), 391-396. doi: https://doi.org/10.1016/j.jamda.2010.04.014
Palop, M., Párraga, J., Lozano, E., & Arteaga, M. (2015). Intervención en la sarcopenia con entrenamiento de resistencia progresiva y suplementos nutricionales proteicos.Nutrición Hospitalaria, 31(4), 1481-1490. Recuperado de: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112015000400004
Papanicolaou, D. A., Ather, S. N., Zhu, H., Zhou, Y., Lutkiewicz, J., Scott, B. B., & Chandler, J. (2013). A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia.The journal of nutrition, health & aging, 17(6), 533-543. doi: 10.1007/s12603-013-0335-x.
Perreault, K., Courchesne-Loyer, A., Fortier, M., Maltais, M., Barsalani, R., Riesco, E., & Dionne, I. J. (2016). Sixteen weeks of resistance training decrease plasma heat shock protein 72 (eHSP72) and increase muscle mass without affecting high sensitivity inflammatory markers’ levels in sarcopenic men.Aging clinical and experimental research, 28(2), 207-214. doi: 10.1007/s40520-015-0411-7.
Peterson, M., Rhea, M., Sen, A., & Gordon, P. (2010). Resistance exercise for muscular strength in older adults: a meta-analysis. Ageing research reviews, 9(3), 226-237. doi: https://doi.org/10.1016/j.arr.2010.03.004
Phillips, S., Tang, J., & Moore, D. (2009). The role of milk-and soy-based protein in support of muscle protein synthesis and muscle protein accretion in young and elderly persons. Journal of the American College of Nutrition, 28(4), 343-354. doi: https://doi.org/10.1080/07315724.2009.10718096
Rolland, Y., Onder, G., Morley, J. E., Gillette-Guyonet, S., van Kan, G. A., & Vellas, B. (2011). Current and future pharmacologic treatment of sarcopenia. Clinics in geriatric medicine, 27(3), 423-447. doi: https://doi.org/10.1016/j.cger.2011.03.008
Rosenberg, I. (1989). Summary comments. The American Journal of Clinical Nutrition, 50(5), 1231–1233. doi: https://doi.org/10.1093/ajcn/50.5.1231
Rosenberg, I. (1997). Sarcopenia: origins and clinical relevance. The Journal of nutrition, 127(5), 990S-991S. doi: https://doi.org/10.1093/jn/127.5.990S
Shahar, S., Kamaruddin, N., Badrasawi, M., Sakian, N., Manaf, Z., Yassin, Z., & Joseph, L. (2013). Effectiveness of exercise and protein supplementation intervention on body composition, functional fitness, and oxidative stress among elderly Malays with sarcopenia.Clinical interventions in aging, 8, 1365-1375. doi: https://dx.doi.org/10.2147%2FCIA.S46826
Smart, N., Waldron, M., Ismail, H., Giallauria, F., Vigorito, C., Cornelissen, V., & Dieberg, G. (2015). Validation of a new tool for the assessment of study quality and reporting in exercise training studies: TESTEX.International journal of evidence-based healthcare,13(1), 9-18. doi: 10.1097/XEB.0000000000000020
Solano, W. y Carazo, P. (2018). Intervenciones con ejercicio contra-resistencia en la persona adulta mayor diagnosticada con sarcopenia. Una revisión sistemática. Pensar en Movimiento: Revista de Ciencias del Ejercicio y la Salud, 16(1), 1-19. doi: https://doi.org/10.15517/pensarmov.v16i1.30000
Spangenburg, E. E. (2009). Changes in muscle mass with mechanical load: Possible cellular mechanisms. Applied Physiolgy, Nutrition and Metabolism, 34, 328-335. Recuperado de: http://www.nrcresearchpress.com/doi/abs/10.1139/H09-010#.W3esF-hKjIU
Tortora, G., & Derrickson, B. (2013). Principios de anatomía y fisiología. Panamericana. Recuperado de: https://www.medicapanamericana.com/tortora/
Vary, T., & Lynch, C. (2007). Nutrient signaling components controlling protein synthesis in striated muscle. The Journal of Nutrition, 137(8), 1835-1843. doi: https://doi.org/10.1093/jn/137.8.1835
Vásquez, A., Wanden, C., & Sanz, J. (2013). Ejercicio físico y suplementos nutricionales: efectos de su uso combinado en las personas mayores de 65 años; una revisión sistemática.Nutrición hospitalaria,28(4), 1077-1084. Recuperado de: http://scielo.isciii.es/pdf/nh/v28n4/14original05.pdf
Wei, N., Pang, M. Y., Ng, S. S., & Ng, G. Y. (2017). Optimal frequency/time combination of whole‐body vibration training for improving muscle size and strength of people with age‐related muscle loss (sarcopenia): A randomized controlled trial.Geriatrics & gerontology international, 17(10), 1412-1420. doi: https://doi.org/10.1111/ggi.12878
Wright, J., & Baldwin, C. (2017). Oral nutritional support with or without exercise in the management of malnutrition in nutritionally vulnerable older people: A systematic review and meta-analysis.Clinical Nutrition. doi: https://doi.org/10.1016 /j.clnu.2017.09.004
Yamamoto, K., Nagatsuma, Y., Fukuda, Y., Hirao, M., Nishikawa, K., Miyamoto, A., ... & Tsujinaka, T. (2017). Effectiveness of a preoperative exercise and nutritional support program for elderly sarcopenic patients with gastric cancer. Gastric Cancer, 20(5), 913-918. doi: https://doi.org/10.1007/s10120-016-0683-4
Zdzieblik, D., Oesser, S., Baumstark, M., Gollhofer, A., & König, D. (2015). Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. British Journal of Nutrition, 114(8), 1237-1245. doi: https://doi.org/10.1017/S0007114515002810
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Derechos de autor 2019 Wilson Solano García, Pedro Carazo Vargas